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龙图腾网恭喜IP2IPO创新有限公司申请的专利新颖的化合物获国家发明授权专利权，本发明授权专利权由国家知识产权局授予，授权公告号为：CN114450300B 。

龙图腾网通过国家知识产权局官网在2025-05-20发布的发明授权授权公告中获悉：该发明授权的专利申请号/专利号为：202080051458.3，技术领域涉及：C07K14/605；该发明授权新颖的化合物是由S·R·布鲁姆设计研发完成，并于2020-06-12向国家知识产权局提交的专利申请。

本新颖的化合物在说明书摘要公布了：本发明提供了新颖的化合物，所述新颖的化合物是肽类激素类似物，并且可用于治疗如糖尿病和肥胖症等病症。关于对胰高血糖素和GLP‑1受体的效力特性，说明书中列举的一般序列的化合物具有定制的分布。关于体内特性，已经在动物模型中证明施用本发明的示例肽会导致体重减轻增加。优选的化合物在不显着减少食物摄入量的情况下实现这一点。

本发明授权新颖的化合物在权利要求书中公布了：1.一种式I化合物：X-W-Y1-Y2式I其中X是氨基酸序列：His1-Xaa2-Xaa3-Gly4-Thr5-Phe6-Thr7-Ser8-Asp9-Xaa10-Ser11-Xaa12-Xaa13-Leu14-Xaa15-Xaa16-Xaa17-Xaa18-Xaa19-Xaa20-Xaa21-Phe22-Xaa23-Xaa24-Trp25-Leu26-Xaa27-Xaa28-Xaa29-[SEQIDNO:742]W是氨基酸序列：-Xaa30-Xaa31-Xaa32-Xaa33-Xaa34-[SEQIDNO:795]；Y1是氨基酸序列：-Xaa35-Xaa36-Xaa37-Xaa38-Xaa39-Xaa40-Xaa41-Lys42-Xaa43-Xaa44[SEQIDNO:744]并且位置42的赖氨酸残基在其ε-氨基处被Y2基团取代并且Y2是：Z-Xaa45-Xaa46-Xaa47-Xaa48-[SEQIDNO:745]并且Z为下式的基团： 其中R为C8-C28亚烷基或亚烯基，并且R1是CO2H，并且其中所述式I的化合物选自：实例号.136:His1-AIB2-His3-Gly4-Thr5-Phe6-Thr7-Ser8-Asp9-Tyr10-Ser11-Lys12-Tyr13-Leu14-Asp15-Ala16-Lys17-Arg18-Ala19-Gln20-Glu21-Phe22-Ile23-Glu24-Trp25-Leu26-Leu27-Gln28-Ser29-His30-His31-His32-His33-His34-Pro35-Ser36-Pro37-Pro38-Pro39-Gly40-Lys42；Y2＝Z-Thr47-His48-；Z＝i；R为C18直链亚烷基；实例号.163:His1-AIB2-His3-Gly4-Thr5-Phe6-Thr7-Ser8-Asp9-Tyr10-Ser11-Lys12-Tyr13-Leu14-Asp15-Ala16-Lys17-Arg18-Ala19-Gln20-Glu21-Phe22-Ile23-Glu24-Trp25-Leu26-Leu27-Gln28-Ser29-His30-His31-His32-His33-His34-Glu35-Ser36-Pro37-Pro38-Pro39-Gly40-Lys42；Y2＝Z-Gly47-Ser48-；Z＝i；R为C16直链亚烷基；实例号.167:His1-AIB2-His3-Gly4-Thr5-Phe6-Thr7-Ser8-Asp9-Tyr10-Ser11-Lys12-Tyr13-Leu14-Asp15-Ala16-Lys17-Arg18-Ala19-Gln20-Glu21-Phe22-Ile23-Glu24-Trp25-Leu26-Leu27-Gln28-Ser29-His30-His31-His32-His33-His34-Glu35-Ser36-Pro37-Pro38-Pro39-Gly40-Lys42；Y2＝Z-Ser46-Gly47-Thr48-；Z＝i；R为C18直链亚烷基；实例号.168:His1-AIB2-His3-Gly4-Thr5-Phe6-Thr7-Ser8-Asp9-Tyr10-Ser11-Lys12-Tyr13-Leu14-Asp15-Ala16-Lys17-Arg18-Ala19-Gln20-Glu21-Phe22-Ile23-Glu24-Trp25-Leu26-Leu27-Gln28-Ser29-His30-His31-His32-His33-His34-Glu35-Ser36-Pro37-Pro38-Pro39-Gly40-Lys42；Y2＝Z-Gly45-Ser46-Gly47-Ser48-；Z＝i；R为C18直链亚烷基；实例号.169:His1-AIB2-His3-Gly4-Thr5-Phe6-Thr7-Ser8-Asp9-Tyr10-Ser11-Lys12-Tyr13-Leu14-Asp15-Ala16-Lys17-Arg18-Ala19-Gln20-Glu21-Phe22-Ile23-Glu24-Trp25-Leu26-Leu27-Gln28-Ser29-His30-His31-His32-His33-His34-Glu35-Ser36-Pro37-Pro38-Pro39-Gly40-Lys42；Y2＝Z-Thr47-His48-；Z＝i；R为C18直链亚烷基；实例号.176:His1-AIB2-His3-Gly4-Thr5-Phe6-Thr7-Ser8-Asp9-Tyr10-Ser11-Lys12-Tyr13-Leu14-Asp15-Ala16-Lys17-Arg18-Ala19-Gln20-Glu21-Phe22-Ile23-Glu24-Trp25-Leu26-Leu27-Gln28-Ser29-His30-His31-His32-His33-His34-Pro35-Ser36-Pro37-Pro38-Pro39-Gly40-Lys42；Y2＝Z-Gly45-Ser46-Gly47-Ser48-；Z＝i；R为C18直链亚烷基；实例号.195:His1-AIB2-His3-Gly4-Thr5-Phe6-Thr7-Ser8-Asp9-Tyr10-Ser11-Lys12-Tyr13-Leu14-Asp15-Ala16-Lys17-Arg18-Ala19-Gln20-Glu21-Phe22-Ile23-Glu24-Trp25-Leu26-Leu27-Gln28-Ser29-His30-His31-His32-His33-His34-Pro35-Ser36-Pro37-Pro38-Pro39-Gly40-Lys42；Y2＝Z-Ser46-Asn47-Thr48-；Z＝i；R为C18直链亚烷基；实例号.196:His1-AIB2-His3-Gly4-Thr5-Phe6-Thr7-Ser8-Asp9-Tyr10-Ser11-Lys12-Tyr13-Leu14-Asp15-Ala16-Lys17-Arg18-Ala19-Gln20-Glu21-Phe22-Ile23-Glu24-Trp25-Leu26-Leu27-Gln28-Ser29-His30-His31-His32-His33-His34-Pro35-Ser36-Pro37-Pro38-Pro39-Gly40-Lys42；Y2＝Z-Ser46-Gln47-Thr48-；Z＝i；R为C18直链亚烷基；实例号.197:His1-AIB2-His3-Gly4-Thr5-Phe6-Thr7-Ser8-Asp9-Tyr10-Ser11-Lys12-Tyr13-Leu14-Asp15-Ala16-Lys17-Arg18-Ala19-Gln20-Glu21-Phe22-Ile23-Glu24-Trp25-Leu26-Leu27-Gln28-Ser29-His30-His31-His32-His33-His34-Pro35-Ser36-Pro37-Pro38-Pro39-Gly40-Lys42；Y2＝Z-Gly46-Gln47-Thr48-；Z＝i；R为C18直链亚烷基；实例号.198:His1-AIB2-His3-Gly4-Thr5-Phe6-Thr7-Ser8-Asp9-Tyr10-Ser11-Lys12-Tyr13-Leu14-Asp15-Ala16-Lys17-Arg18-Ala19-Gln20-Glu21-Phe22-Ile23-Glu24-Trp25-Leu26-Leu27-Gln28-Ser29-His30-His31-His32-His33-His34-Pro35-Ser36-Pro37-Pro38-Pro39-Gly40-Lys42；Y2＝Z-Gln47-Thr48-；Z＝i；R为C18直链亚烷基；实例号.199:His1-AIB2-His3-Gly4-Thr5-Phe6-Thr7-Ser8-Asp9-Tyr10-Ser11-Lys12-Tyr13-Leu14-Asp15-Ala16-Lys17-Arg18-Ala19-Gln20-Glu21-Phe22-Ile23-Glu24-Trp25-Leu26-Leu27-Gln28-Ser29-His30-His31-His32-His33-His34-Pro35-Ser36-Pro37-Pro38-Pro39-Gly40-Lys42；Y2＝Z-Thr47-Gln48-；Z＝i；R为C18直链亚烷基；实例号.200:His1-AIB2-His3-Gly4-Thr5-Phe6-Thr7-Ser8-Asp9-Tyr10-Ser11-Lys12-Tyr13-Leu14-Asp15-Ala16-Lys17-Arg18-Ala19-Gln20-Glu21-Phe22-Ile23-Glu24-Trp25-Leu26-Leu27-Gln28-Ser29-His30-His31-His32-His33-His34-Pro35-Ser36-Pro37-Pro38-Pro39-Gly40-Lys42；Y2＝Z-His47-Thr48-；Z＝i；R为C18直链亚烷基；实例号.201:His1-AIB2-His3-Gly4-Thr5-Phe6-Thr7-Ser8-Asp9-Tyr10-Ser11-Lys12-Tyr13-Leu14-Asp15-Ala16-Lys17-Arg18-Ala19-Gln20-Glu21-Phe22-Ile23-Glu24-Trp25-Leu26-Leu27-Gln28-Ser29-His30-His31-His32-His33-His34-Pro35-Ser36-Pro37-Pro38-Pro39-Gly40-Lys42；Y2＝Z-Asn47-His48-；Z＝i；R为C16直链亚烷基；实例号.202:His1-AIB2-His3-Gly4-Thr5-Phe6-Thr7-Ser8-Asp9-Tyr10-Ser11-Lys12-Tyr13-Leu14-Asp15-Ala16-Lys17-Arg18-Ala19-Gln20-Glu21-Phe22-Ile23-Glu24-Trp25-Leu26-Leu27-Gln28-Ser29-His30-His31-His32-His33-His34-Pro35-Ser36-Pro37-Pro38-Pro39-Gly40-Lys42；Y2＝Z-Thr47-His48-；Z＝i；R为C14直链亚烷基；实例号.203:His1-AIB2-His3-Gly4-Thr5-Phe6-Thr7-Ser8-Asp9-Tyr10-Ser11-Lys12-Tyr13-Leu14-Asp15-Ala16-Lys17-Arg18-Ala19-Gln20-Glu21-Phe22-Ile23-Glu24-Trp25-Leu26-Leu27-Gln28-Ser29-His30-His31-His32-His33-His34-Pro35-Ser36-Pro37-Pro38-Pro39-Gly40-Lys42；Y2＝Z-His48-；Z＝i；R为C18直链亚烷基；实例号.204:His1-AIB2-His3-Gly4-Thr5-Phe6-Thr7-Ser8-Asp9-Tyr10-Ser11-Lys12-Tyr13-Leu14-Asp15-Ala16-Lys17-Arg18-Ala19-Gln20-Glu21-Phe22-Ile23-Glu24-Trp25-Leu26-Leu27-Gln28-Ser29-His30-His31-His32-His33-His34-Pro35-Ser36-Pro37-Pro38-Pro39-Gly40-Lys42；Y2＝Z-Asn48-；Z＝i；R为C18直链亚烷基；实例号.205:His1-AIB2-His3-Gly4-Thr5-Phe6-Thr7-Ser8-Asp9-Tyr10-Ser11-Lys12-Tyr13-Leu14-Asp15-Ala16-Lys17-Arg18-Ala19-Gln20-Glu21-Phe22-Ile23-Glu24-Trp25-Leu26-Leu27-Gln28-Ser29-His30-His31-His32-His33-His34-Pro35-Ser36-Pro37-Pro38-Pro39-Gly40-Lys42；Y2＝Z-Gln48-；Z＝i；R为C18直链亚烷基；实例号.211:His1-AIB2-His3-Gly4-Thr5-Phe6-Thr7-Ser8-Asp9-Tyr10-Ser11-Lys12-Tyr13-Leu14-Asp15-Ala16-Lys17-Arg18-Ala19-Gln20-Glu21-Phe22-Ile23-Glu24-Trp25-Leu26-Leu27-Gln28-Ser29-His30-His31-His32-His33-His34-Pro35-Ser36-Pro37-Pro38-Pro39-Gly40-Lys42；Y2＝Z-Ser46-Gly47-Thr48-；Z＝i；R为C18直链亚烷基；实例号.255:His1-AIB2-His3-Gly4-Thr5-Phe6-Thr7-Ser8-Asp9-Tyr10-Ser11-Lys12-Tyr13-Leu14-Asp15-Ala16-Lys17-Arg18-Ala19-Gln20-Glu21-Phe22-Ile23-Glu24-Trp25-Leu26-Leu27-Gln28-Ser29-His30-His31-His32-His33-His34-Glu35-Ser36-Pro37-Pro38-Pro39-Gly40-Lys42；Y2＝Z-Ser46-Gly47-Thr48-；Z＝i；R为C20直链亚烷基；实例号.256:His1-AIB2-His3-Gly4-Thr5-Phe6-Thr7-Ser8-Asp9-Tyr10-Ser11-Lys12-Tyr13-Leu14-Asp15-Ala16-Lys17-Arg18-Ala19-Gln20-Glu21-Phe22-Ile23-Glu24-Trp25-Leu26-Leu27-Gln28-Ser29-His30-His31-His32-His33-His34-Glu35-Ser36-Pro37-Pro38-Pro39-Gly40-Lys42；Y2＝Z-Gly45-Ser46-Gly47-Ser48-；Z＝i；R为C20直链亚烷基；实例号.260:His1-AIB2-His3-Gly4-Thr5-Phe6-Thr7-Ser8-Asp9-Tyr10-Ser11-Lys12-Tyr13-Leu14-Asp15-Ala16-Lys17-Arg18-Ala19-Gln20-Glu21-Phe22-Ile23-Glu24-Trp25-Leu26-Leu27-Gln28-Ser29-His30-His31-His32-His33-His34-Glu35-Ser36-Pro37-Pro38-Pro39-Gly40-Lys42；Y2＝Z-Ser46-Gly47-Thr48-；Z＝i；R为C22直链亚烷基；实例号.261:His1-AIB2-His3-Gly4-Thr5-Phe6-Thr7-Ser8-Asp9-Tyr10-Ser11-Lys12-Tyr13-Leu14-Asp15-Ala16-Lys17-Arg18-Ala19-Gln20-Glu21-Phe22-Ile23-Glu24-Trp25-Leu26-Leu27-Gln28-Ser29-His30-His31-His32-His33-His34-Glu35-Ser36-Pro37-Pro38-Pro39-Gly40-Lys42；Y2＝Z-Gly45-Ser46-Gly47-Ser48-；Z＝i；R为C22直链亚烷基；实例号.262:His1-AIB2-His3-Gly4-Thr5-Phe6-Thr7-Ser8-Asp9-Tyr10-Ser11-Lys12-Tyr13-Leu14-Asp15-Ala16-Lys17-Arg18-Ala19-Gln20-Glu21-Phe22-Ile23-Glu24-Trp25-Leu26-Leu27-Gln28-Ser29-His30-His31-Gln32-His33-His34-Pro35-Ser36-Pro37-Pro38-Pro39-Gly40-Lys42；Y2＝Z-Asn48-；Z＝i；R为C18直链亚烷基；实例号.263:His1-AIB2-His3-Gly4-Thr5-Phe6-Thr7-Ser8-Asp9-Tyr10-Ser11-Lys12-Tyr13-Leu14-Asp15-Ala16-Lys17-Arg18-Ala19-Gln20-Glu21-Phe22-Ile23-Glu24-Trp25-Leu26-Leu27-Gln28-Ser29-His30-His31-Gln32-His33-His34-Pro35-Ser36-Pro37-Pro38-Pro39-Gly40-Lys42；Y2＝Z-Gln48-；Z＝i；R为C18直链亚烷基；实例号.264:His1-AIB2-His3-Gly4-Thr5-Phe6-Thr7-Ser8-Asp9-Tyr10-Ser11-Lys12-Tyr13-Leu14-Asp15-Ala16-Lys17-Arg18-Ala19-Gln20-Glu21-Phe22-Ile23-Glu24-Trp25-Leu26-Leu27-Gln28-Ser29-His30-His31-His32-His33-His34-Pro35-Ser36-Pro37-Pro38-Pro39-Gly40-Lys42；Y2＝Z-Asn48-；Z＝i；R为C20直链亚烷基；实例号.265:His1-AIB2-His3-Gly4-Thr5-Phe6-Thr7-Ser8-Asp9-Tyr10-Ser11-Lys12-Tyr13-Leu14-Asp15-Ala16-Lys17-Arg18-Ala19-Gln20-Glu21-Phe22-Ile23-Glu24-Trp25-Leu26-Leu27-Gln28-Ser29-His30-His31-His32-His33-His34-Pro35-Ser36-Pro37-Pro38-Pro39-Gly40-Lys42；Y2＝Z-Gln48-；Z＝i；R为C20直链亚烷基；实例号.266:His1-AIB2-His3-Gly4-Thr5-Phe6-Thr7-Ser8-Asp9-Tyr10-Ser11-Lys12-Tyr13-Leu14-Asp15-Ala16-Lys17-Arg18-Ala19-Gln20-Glu21-Phe22-Ile23-Glu24-Trp25-Leu26-Leu27-Gln28-Ser29-His30-His31-His32-His33-His34-Pro35-Ser36-Pro37-Pro38-Pro39-Lys42；Y2＝Z-Gln48-；Z＝i；R为C18直链亚烷基；实例号.267:His1-AIB2-His3-Gly4-Thr5-Phe6-Thr7-Ser8-Asp9-Tyr10-Ser11-Lys12-Tyr13-Leu14-Asp15-Ala16-Lys17-Arg18-Ala19-Gln20-Glu21-Phe22-Ile23-Glu24-Trp25-Leu26-Leu27-Gln28-Ser29-His30-His31-His32-His33-His34-Pro35-Ser36-Pro37-Pro38-Lys42；Y2＝Z-Gln48-；Z＝i；R为C18直链亚烷基；实例号.268:His1-AIB2-His3-Gly4-Thr5-Phe6-Thr7-Ser8-Asp9-Tyr10-Ser11-Lys12-Tyr13-Leu14-Asp15-Ala16-Lys17-Arg18-Ala19-Gln20-Glu21-Phe22-Ile23-Glu24-Trp25-Leu26-Leu27-Gln28-Ser29-His30-His31-His32-His33-His34-Pro35-Ser36-Pro37-Pro38-Gly39-Lys42；Y2＝Z-Gln48-；Z＝i；R为C18直链亚烷基；实例号.269:His1-AIB2-His3-Gly4-Thr5-Phe6-Thr7-Ser8-Asp9-Tyr10-Ser11-Lys12-Tyr13-Leu14-Asp15-Ala16-Lys17-Arg18-Ala19-Gln20-Glu21-Phe22-Ile23-Glu24-Trp25-Leu26-Leu27-Gln28-Ser29-His30-His31-His32-His33-His34-Pro35-Ser36-Pro37-Pro38-Pro39-Gly40-Lys42；Y2＝Z-Gln48-；Z＝i；R为C18直链亚烷基；实例号.270:His1-AIB2-His3-Gly4-Thr5-Phe6-Thr7-Ser8-Asp9-Tyr10-Ser11-Lys12-Tyr13-Leu14-Asp15-Ala16-Lys17-Arg18-Ala19-Gln20-Glu21-Phe22-Ile23-Glu24-Trp25-Leu26-Leu27-Gln28-Ser29-His30-His31-His32-His33-His34-Pro35-Ser36-Pro37-Pro38-Pro39-Gly40-Lys42；Y2＝Z-Gln47-Gly48-；Z＝i；R为C18直链亚烷基；实例号.271:His1-AIB2-His3-Gly4-Thr5-Phe6-Thr7-Ser8-Asp9-Tyr10-Ser11-Lys12-Tyr13-Leu14-Asp15-Ala16-Lys17-Arg18-Ala19-Gln20-Glu21-Phe22-Ile23-Glu24-Trp25-Leu26-Leu27-Gln28-Ser29-His30-His31-His32-His33-His34-Pro35-Ser36-Pro37-Pro38-Pro39-Gly40-Lys42；Y2＝Z-Gly47-Gln48-；Z＝i；R为C18直链亚烷基；实例号.272:His1-AIB2-His3-Gly4-Thr5-Phe6-Thr7-Ser8-Asp9-Tyr10-Ser11-Lys12-Tyr13-Leu14-Asp15-Ala16-Lys17-Arg18-Ala19-Gln20-Glu21-Phe22-Ile23-Glu24-Trp25-Leu26-Leu27-Gln28-Ser29-His30-His31-His32-His33-His34-Pro35-Ser36-Pro37-Pro38-Pro39-Gly40-Lys42；Y2＝Z-Gly47-Gln48-；Z＝i；R为C22直链亚烷基；实例号.273:His1-AIB2-His3-Gly4-Thr5-Phe6-Thr7-Ser8-Asp9-Tyr10-Ser11-Lys12-Tyr13-Leu14-Asp15-Ala16-Lys17-Arg18-Ala19-Gln20-Glu21-Phe22-Ile23-Glu24-Trp25-Leu26-Leu27-Gln28-Ser29-His30-His31-His32-His33-His34-Glu35-Ser36-Pro37-Pro38-Pro39-Gly40-Lys42；Y2＝Z-Ser46-Gly47-Thr48-；Z＝i；R为C18直链亚烷基；实例号.276:His1-AIB2-His3-Gly4-Thr5-Phe6-Thr7-Ser8-Asp9-Tyr10-Ser11-Lys12-Tyr13-Leu14-Asp15-Ala16-Lys17-Arg18-Ala19-Gln20-Glu21-Phe22-Ile23-Glu24-Trp25-Leu26-Leu27-Gln28-Ser29-His30-His31-His32-His33-His34-Glu35-Ser36-Pro37-Pro38-Pro39-Gly40-Lys42；Y2＝Z-Gln48-；Z＝i；R为C18直链亚烷基；实例号.277:His1-AIB2-His3-Gly4-Thr5-Phe6-Thr7-Ser8-Asp9-Tyr10-Ser11-Lys12-Tyr13-Leu14-Asp15-Ala16-Lys17-Arg18-Ala19-Gln20-Glu21-Phe22-Ile23-Glu24-Trp25-Leu26-Leu27-Gln28-Ser29-His30-His31-Gln32-His33-His34-Pro35-Ser36-Pro37-Pro38-Pro39-Gly40-Lys42；Y2＝Z-Ser46-Gly47-Thr48-；Z＝i；R为C18直链亚烷基；实例号.278:His1-AIB2-His3-Gly4-Thr5-Phe6-Thr7-Ser8-Asp9-Tyr10-Ser11-Lys12-Tyr13-Leu14-Asp15-Ala16-Lys17-Arg18-Ala19-Gln20-Glu21-Phe22-Ile23-Glu24-Trp25-Leu26-Leu27-Gln28-Ser29-His30-His31-His32-His33-His34-Pro35-Ser36-Pro37-Pro38-Pro39-Gly40-Lys42；Y2＝Z-Gln48-；Z＝i；R为C16直链亚烷基；实例号.289:His1-AIB2-His3-Gly4-Thr5-Phe6-Thr7-Ser8-Asp9-Tyr10-Ser11-Lys12-Tyr13-Leu14-Asp15-Ala16-Lys17-Arg18-Ala19-Gln20-Glu21-Phe22-Ile23-Glu24-Trp25-Leu26-Leu27-Gln28-Ser29-His30-His31-His32-His33-His34-Pro35-Ser36-Pro37-Pro38-Pro39-Gly40-Lys42；Y2＝Z-Ser46-Gly47-Thr48-；Z＝i；R为C16直链亚烷基；实例号.290:His1-AIB2-His3-Gly4-Thr5-Phe6-Thr7-Ser8-Asp9-Tyr10-Ser11-Lys12-Tyr13-Leu14-Asp15-Ala16-Lys17-Arg18-Ala19-Gln20-Glu21-Phe22-Ile23-Glu24-Trp25-Leu26-Leu27-Gln28-Ser29-His30-His31-His32-His33-His34-Pro35-Ser36-Pro37-Pro38-Pro39-Gly40-Lys42；Y2＝Z-Gly47-Ser48-；Z＝i；R为C16直链亚烷基；实例号.301:His1-AIB2-His3-Gly4-Thr5-Phe6-Thr7-Ser8-Asp9-Tyr10-Ser11-Lys12-Tyr13-Leu14-Asp15-Ala16-Lys17-Arg18-Ala19-Gln20-Glu21-Phe22-Ile23-Glu24-Trp25-Leu26-Leu27-Gln28-Ser29-His30-His31-His32-His33-His34-Pro35-Ser36-Pro37-Pro38-Pro39-Gly40-Lys42；Y2＝Z-Asn47-His48-；Z＝i；R为C16直链亚烷基；实例号.314:His1-AIB2-His3-Gly4-Thr5-Phe6-Thr7-Ser8-Asp9-Tyr10-Ser11-Lys12-Tyr13-Leu14-Asp15-Ala16-Lys17-Arg18-Ala19-Gln20-Glu21-Phe22-Ile23-Glu24-Trp25-Leu26-Leu27-Gln28-Ser29-His30-His31-His32-His33-His34-Pro35-Ser36-Pro37-Pro38-Pro39-Gly40-Lys42；Y2＝Z-Asn47-His48-；Z＝i；R为C18直链亚烷基；实例号.315:His1-AIB2-His3-Gly4-Thr5-Phe6-Thr7-Ser8-Asp9-Tyr10-Ser11-Lys12-Tyr13-Leu14-Asp15-Ala16-Lys17-Arg18-Ala19-Gln20-Glu21-Phe22-Ile23-Glu24-Trp25-Leu26-Leu27-Gln28-Ser29-His30-His31-His32-His33-His34-Pro35-Ser36-Pro37-Pro38-Pro39-Lys42；Y2＝Z-Asn47-His48-；Z＝i；R为C16直链亚烷基；实例号.316:His1-AIB2-His3-Gly4-Thr5-Phe6-Thr7-Ser8-Asp9-Tyr10-Ser11-Lys12-Tyr13-Leu14-Asp15-Ala16-Lys17-Arg18-Ala19-Gln20-Glu21-Phe22-Ile23-Glu24-Trp25-Leu26-Leu27-Gln28-Ser29-His30-His31-His32-His33-His34-Pro35-Ser36-Pro37-Pro38-Pro39-Gly40-Lys42；Y2＝Z-Gln47-His48-；Z＝i；R为C16直链亚烷基；实例号.317:His1-AIB2-His3-Gly4-Thr5-Phe6-Thr7-Ser8-Asp9-Tyr10-Ser11-Lys12-Tyr13-Leu14-Asp15-Ala16-Lys17-Arg18-Ala19-Gln20-Glu21-Phe22-Ile23-Glu24-Trp25-Leu26-Leu27-Gln28-Ser29-His30-His31-Gln32-His33-His34-Pro35-Ser36-Pro37-Pro38-Pro39-Lys42；Y2＝Z-Asn47-His48-；Z＝i；R为C16直链亚烷基；实例号.319:His1-AIB2-His3-Gly4-Thr5-Phe6-Thr7-Ser8-Asp9-Tyr10-Ser11-Lys12-Tyr13-Leu14-Asp15-Ala16-Lys17-Arg18-Ala19-Gln20-Glu21-Phe22-Ile23-Glu24-Trp25-Leu26-Leu27-Gln28-Ser29-His30-His31-Gln32-His33-His34-Glu35-Ser36-Pro37-Pro38-Pro39-Lys42；Y2＝Z-Asn47-His48-；Z＝i；R为C16直链亚烷基；实例号.321:His1-AIB2-His3-Gly4-Thr5-Phe6-Thr7-Ser8-Asp9-Tyr10-Ser11-Lys12-Tyr13-Leu14-Asp15-Ala16-Lys17-Arg18-Ala19-Gln20-Glu21-Phe22-Ile23-Glu24-Trp25-Leu26-Leu27-Gln28-Ser29-His30-His31-His32-His33-His34-Glu35-Ser36-Pro37-Pro38-Pro39-Gly40-Lys42；Y2＝Z-Asn47-His48-；Z＝i；R为C16直链亚烷基；实例号.323:His1-AIB2-His3-Gly4-Thr5-Phe6-Thr7-Ser8-Asp9-Tyr10-Ser11-Lys12-Tyr13-Leu14-Asp15-Ala16-Lys17-Arg18-Ala19-Gln20-Glu21-Phe22-Ile23-Glu24-Trp25-Leu26-Leu27-Gln28-Ser29-His30-His31-Gln32-His33-His34-Glu35-Ser36-Pro37-Pro38-Pro39-Gly40-Lys42；Y2＝Z-Asn47-His48-；Z＝i；R为C16直链亚烷基；实例号.325:His1-AIB2-His3-Gly4-Thr5-Phe6-Thr7-Ser8-Asp9-Tyr10-Ser11-Lys12-Tyr13-Leu14-Asp15-Ala16-Lys17-Arg18-Ala19-Gln20-Glu21-Phe22-Ile23-Glu24-Trp25-Leu26-Leu27-Gln28-Ser29-His30-His31-Gln32-His33-His34-Glu35-Ser36-Pro37-Pro38-Pro39-Gly40-Lys42；Y2＝Z-Asn48-；Z＝i；R为C18直链亚烷基；实例号.327:His1-AIB2-His3-Gly4-Thr5-Phe6-Thr7-Ser8-Asp9-Tyr10-Ser11-Lys12-Tyr13-Leu14-Asp15-Ala16-Lys17-Arg18-Ala19-Gln20-Glu21-Phe22-Ile23-Glu24-Trp25-Leu26-Leu27-Gln28-Ser29-His30-His31-Gln32-His33-His34-Glu35-Ser36-Pro37-Pro38-Pro39-Lys42；Y2＝Z-Asn48-；Z＝i；R为C18直链亚烷基；实例号.329:His1-AIB2-His3-Gly4-Thr5-Phe6-Thr7-Ser8-Asp9-Tyr10-Ser11-Lys12-Tyr13-Leu14-Asp15-Ala16-Lys17-Arg18-Ala19-Gln20-Glu21-Phe22-Ile23-Glu24-Trp25-Leu26-Leu27-Gln28-Ser29-His30-His31-Gln32-His33-His34-Pro35-Ser36-Pro37-Pro38-Pro39-Gly40-Lys42；Y2＝Z-Asn48-；Z＝i；R为C16直链亚烷基；实例号.340:His1-AIB2-His3-Gly4-Thr5-Phe6-Thr7-Ser8-Asp9-Tyr10-Ser11-Lys12-Tyr13-Leu14-Asp15-Ala16-Lys17-Arg18-Ala19-Gln20-Glu21-Phe22-Ile23-Glu24-Trp25-Leu26-Leu27-Gln28-Ser29-His30-His31-Gln32-His33-His34-Pro35-Ser36-Pro37-Pro38-Pro39-Gly40-Lys42；Y2＝Z-Ser46-Gly47-Thr48-；Z＝i；R为C14直链亚烷基；实例号.341:His1-AIB2-His3-Gly4-Thr5-Phe6-Thr7-Ser8-Asp9-Tyr10-Ser11-Lys12-Tyr13-Leu14-Asp15-Ala16-Lys17-Arg18-Ala19-Gln20-Glu21-Phe22-Ile23-Glu24-Trp25-Leu26-Leu27-Gln28-Ser29-His30-His31-His32-His33-His34-Pro35-Ser36-Pro37-Pro38-Pro39-Gly40-Lys42；Y2＝Z-Gly47-Ser48-；Z＝i；R为C14直链亚烷基；实例号.366:His1-AIB2-His3-Gly4-Thr5-Phe6-Thr7-Ser8-Asp9-Tyr10-Ser11-Lys12-Tyr13-Leu14-Asp15-Ala16-Lys17-Arg18-Ala19-Gln20-Glu21-Phe22-Ile23-Glu24-Trp25-Leu26-Leu27-Gln28-Ser29-His30-His31-Gln32-His33-His34-Pro35-Ser36-Pro37-Pro38-Pro39-Lys42；Y2＝Z-Gly47-Ser48-；Z＝i；R为C16直链亚烷基；实例号.367:His1-AIB2-His3-Gly4-Thr5-Phe6-Thr7-Ser8-Asp9-Tyr10-Ser11-Lys12-Tyr13-Leu14-Asp15-Ala16-Lys17-Arg18-Ala19-Gln20-Glu21-Phe22-Ile23-Glu24-Trp25-Leu26-Leu27-Gln28-Ser29-His30-His31-Gln32-His33-His34-Pro35-Ser36-Pro37-Pro38-Pro39-Lys42；Y2＝Z-Thr45-Gly46-Ser47-Gly48-；Z＝i；R为C16直链亚烷基；实例号.368:His1-AIB2-His3-Gly4-Thr5-Phe6-Thr7-Ser8-Asp9-Tyr10-Ser11-Lys12-Tyr13-Leu14-Asp15-Ala16-Lys17-Arg18-Ala19-Gln20-Glu21-Phe22-Ile23-Glu24-Trp25-Leu26-Leu27-Gln28-Ser29-His30-His31-Gln32-His33-His34-Pro35-Ser36-Pro37-Pro38-Pro39-Lys42；Y2＝Z-Asn48-；Z＝i；R为C16直链亚烷基；实例号.369:His1-AIB2-His3-Gly4-Thr5-Phe6-Thr7-Ser8-Asp9-Tyr10-Ser11-Lys12-Tyr13-Leu14-Asp15-Ala16-Lys17-Arg18-Ala19-Gln20-Glu21-Phe22-Ile23-Glu24-Trp25-Leu26-Leu27-Gln28-Ser29-His30-His31-Gln32-His33-His34-Pro35-Ser36-Pro37-Pro38-Pro39-Lys42；Y2＝Z-Gln48-；Z＝i；R为C16直链亚烷基；实例号.412:His1-AIB2-His3-Gly4-Thr5-Phe6-Thr7-Ser8-Asp9-Tyr10-Ser11-Lys12-Tyr13-Leu14-Asp15-Ala16-Lys17-Arg18-Ala19-Gln20-Glu21-Phe22-Ile23-Glu24-Trp25-Leu26-Leu27-Gln28-Ser29-His30-His31-Gln32-His33-His34-Pro35-Ser36-Pro37-Pro38-Pro39-Lys42；Y2＝Z-Thr45-Gly46-Ser47-Gly48-；Z＝i；R为C18直链亚烷基；实例号.521:His1-AIB2-His3-Gly4-Thr5-Phe6-Thr7-Ser8-Asp9-Tyr10-Ser11-Lys12-Tyr13-Leu14-Asp15-Ala16-Lys17-Arg18-Ala19-Gln20-Glu21-Phe22-Ile23-Glu24-Trp25-Leu26-Leu27-Gln28-Ser29-His30-Gln31-His32-Pro33-Ser34-Pro35-Pro36-Pro37-Lys42；Y2＝Z-Asn48-；Z＝i；R为C18直链亚烷基；实例号.536:His1-AIB2-His3-Gly4-Thr5-Phe6-Thr7-Ser8-Asp9-Tyr10-Ser11-Lys12-Tyr13-Leu14-Asp15-Ala16-Lys17-Arg18-Ala19-Gln20-Glu21-Phe22-Ile23-Glu24-Trp25-Leu26-Leu27-Gln28-Ser29-His30-His31-Gln32-His33-His34-Pro35-Ser36-Pro37-Pro38-Pro39-Lys42；Y2＝Z-Asn48-；Z＝i；R为C18直链亚烷基；实例号.537:His1-AIB2-His3-Gly4-Thr5-Phe6-Thr7-Ser8-Asp9-Tyr10-Ser11-Lys12-Tyr13-Leu14-Asp15-Ala16-Lys17-Arg18-Ala19-Gln20-Glu21-Phe22-Ile23-Glu24-Trp25-Leu26-Leu27-Gln28-Ser29-His30-His31-Gln32-His33-His34-Pro35-Ser36-Pro37-Pro38-Pro39-Lys42；Y2＝Z-；Z＝i；R为C18直链亚烷基；实例号.538:His1-AIB2-His3-Gly4-Thr5-Phe6-Thr7-Ser8-Asp9-Tyr10-Ser11-Lys12-Tyr13-Leu14-Asp15-Ala16-Lys17-Arg18-Ala19-Gln20-Glu21-Phe22-Ile23-Glu24-Trp25-Leu26-Leu27-Gln28-Ser29-His30-His31-Gln32-His33-His34-Pro35-Ser36-Pro37-Pro38-Pro39-Gly40-Lys42；Y2＝Z-；Z＝i；R为C18直链亚烷基；实例号.542:His1-AIB2-His3-Gly4-Thr5-Phe6-Thr7-Ser8-Asp9-Tyr10-Ser11-Lys12-Tyr13-Leu14-Asp15-Ala16-Lys17-Arg18-Ala19-Gln20-Glu21-Phe22-Ile23-Glu24-Trp25-Leu26-Leu27-Gln28-Ser29-Gln30-Gln31-His32-Glu33-Ser34-Pro35-Pro36-Pro37-Lys42；Y2＝Z-；Z＝i；R为C18直链亚烷基；实例号.543:His1-AIB2-His3-Gly4-Thr5-Phe6-Thr7-Ser8-Asp9-Tyr10-Ser11-Lys12-Tyr13-Leu14-Asp15-Ala16-Lys17-Arg18-Ala19-Gln20-Glu21-Phe22-Ile23-Glu24-Trp25-Leu26-Leu27-Gln28-Ser29-Gln30-Gln31-His32-Glu33-Ser34-Pro35-Pro36-Pro37-Lys42；Y2＝Z-；Z＝i；R为C18直链亚烷基；实例号.544:His1-AIB2-His3-Gly4-Thr5-Phe6-Thr7-Ser8-Asp9-Tyr10-Ser11-Lys12-Tyr13-Leu14-Asp15-Ala16-Lys17-Arg18-Ala19-Gln20-Glu21-Phe22-Ile23-Glu24-Trp25-Leu26-Leu27-Gln28-Ser29-His30-Gln31-His32-Pro33-Ser34-Pro35-Pro36-Pro37-Lys42；Y2＝Z-；Z＝i；R为C18直链亚烷基；实例号.549:His1-AIB2-His3-Gly4-Thr5-Phe6-Thr7-Ser8-Asp9-Tyr10-Ser11-Lys12-Tyr13-Leu14-Asp15-Ala16-Lys17-Arg18-Ala19-Gln20-Glu21-Phe22-Ile23-Glu24-Trp25-Leu26-Leu27-Gln28-Ser29-His30-His31-Gln32-Gln33-His34-Glu35-Ser36-Pro37-Pro38-Pro39-Lys42；Y2＝Z-Asn48-；Z＝i；R为C18直链亚烷基；实例号.550:His1-AIB2-His3-Gly4-Thr5-Phe6-Thr7-Ser8-Asp9-Tyr10-Ser11-Lys12-Tyr13-Leu14-Asp15-Ala16-Lys17-Arg18-Ala19-Gln20-Glu21-Phe22-Ile23-Glu24-Trp25-Leu26-Leu27-Gln28-Ser29-His30-His31-Gln32-Gln33-His34-Pro35-Ser36-Pro37-Pro38-Pro39-Lys42；Y2＝Z-；Z＝i；R为C18直链亚烷基；实例号.552:His1-AIB2-His3-Gly4-Thr5-Phe6-Thr7-Ser8-Asp9-Tyr10-Ser11-Lys12-Tyr13-Leu14-Asp15-Ala16-Lys17-Arg18-Ala19-Gln20-Glu21-Phe22-Ile23-Glu24-Trp25-Leu26-Leu27-Gln28-Ser29-His30-Gln31-His32-Gln33-His34-Pro35-Ser36-Pro37-Pro38-Pro39-Lys42；Y2＝Z-；Z＝i；R为C18直链亚烷基；实例号.553:His1-AIB2-His3-Gly4-Thr5-Phe6-Thr7-Ser8-Asp9-Tyr10-Ser11-Lys12-Tyr13-Leu14-Asp15-Ala16-Lys17-Arg18-Ala19-Gln20-Glu21-Phe22-Ile23-Glu24-Trp25-Leu26-Leu27-Gln28-Ser29-His30-Gln31-Gln32-Gln33-His34-Pro35-Ser36-Pro37-Pro38-Pro39-Gly40-Lys42；Y2＝Z-；Z＝i；R为C18直链亚烷基；实例号.581:His1-AIB2-His3-Gly4-Thr5-Phe6-Thr7-Ser8-Asp9-Tyr10-Ser11-Lys12-Tyr13-Leu14-Asp15-Ala16-Lys17-Arg18-Ala19-Gln20-Glu21-Phe22-Ile23-Glu24-Trp25-Leu26-Leu27-Gln28-Ser29-His30-Gln31-Gln32-Pro33-Ser34-Pro35-Pro36-Pro37-Lys42；Y2＝Z-；Z＝i；R为C18直链亚烷基；实例号.588:His1-AIB2-His3-Gly4-Thr5-Phe6-Thr7-Ser8-Asp9-Tyr10-Ser11-Lys12-Tyr13-Leu14-Asp15-Ala16-Lys17-Arg18-Ala19-His20-Glu21-Phe22-Ile23-Glu24-Trp25-Leu26-Leu27-Gln28-Ser29-His30-Gln31-Gln32-His33-Glu34-Ser35-Pro36-Pro37-Pro38-Lys42；Y2＝Z-；Z＝i；R为C18直链亚烷基；实例号.589:His1-AIB2-His3-Gly4-Thr5-Phe6-Thr7-Ser8-Asp9-Tyr10-Ser11-Lys12-Tyr13-Leu14-Asp15-Ala16-Lys17-Arg18-Ala19-His20-Glu21-Phe22-Ile23-Glu24-Trp25-Leu26-Leu27-Gln28-Ser29-His30-Gln31-Gln32-His33-Ser34-Pro35-Pro36-Pro37-Lys42；Y2＝Z-Gly47-Ser48-；Z＝i；R为C18直链亚烷基；实例号.590:His1-AIB2-His3-Gly4-Thr5-Phe6-Thr7-Ser8-Asp9-Tyr10-Ser11-Lys12-Tyr13-Leu14-Asp15-Ala16-Lys17-Arg18-Ala19-His20-Glu21-Phe22-Ile23-Glu24-Trp25-Leu26-Leu27-Gln28-Ser29-His30-Gln31-Gln32-His33-Ser34-Pro35-Pro36-Pro37-Lys42；Y2＝Z-；Z＝i；R为C18直链亚烷基；实例号.595:His1-AIB2-His3-Gly4-Thr5-Phe6-Thr7-Ser8-Asp9-Tyr10-Ser11-Lys12-Tyr13-Leu14-Asp15-Ala16-Lys17-Arg18-Ala19-Gln20-Glu21-Phe22-Ile23-Glu24-Trp25-Leu26-Leu27-Gln28-Ser29-His30-Gln31-His32-Glu33-Ser34-Pro35-Pro36-Pro37-Lys42；Y2＝Z-；Z＝i；R为C18直链亚烷基；实例号.597:His1-AIB2-His3-Gly4-Thr5-Phe6-Thr7-Ser8-Asp9-Tyr10-Ser11-Lys12-Tyr13-Leu14-Asp15-Ala16-Lys17-Arg18-Ala19-Gln20-Glu21-Phe22-Ile23-Glu24-Trp25-Leu26-Leu27-Gln28-Ser29-His30-Gln31-His32-Glu33-Ser34-Pro35-Pro36-Pro37-Lys42；Y2＝Z-Asn48-；Z＝i；R为C18直链亚烷基；实例号.598:His1-AIB2-His3-Gly4-Thr5-Phe6-Thr7-Ser8-Asp9-Tyr10-Ser11-Lys12-Tyr13-Leu14-Asp15-Ala16-Lys17-Arg18-Ala19-Gln20-Glu21-Phe22-Ile23-Glu24-Trp25-Leu26-Leu27-Gln28-Ser29-His30-Gln31-Gln32-His33-Glu34-Ser35-Pro36-Pro37-Pro38-Lys42；Y2＝Z-Asn48-；Z＝i；R为C18直链亚烷基；实例号.602:His1-AIB2-His3-Gly4-Thr5-Phe6-Thr7-Ser8-Asp9-Tyr10-Ser11-Lys12-Tyr13-Leu14-Asp15-Ala16-Lys17-Arg18-Ala19-Gln20-Glu21-Phe22-Ile23-Glu24-Trp25-Leu26-Leu27-Gln28-Ser29-His30-Gln31-Gln32-Gln33-His34-Glu35-Ser36-Pro37-Pro38-Pro39-Lys42；Y2＝Z-Asn48-；Z＝i；R为C18直链亚烷基；实例号.603:His1-AIB2-His3-Gly4-Thr5-Phe6-Thr7-Ser8-Asp9-Tyr10-Ser11-Lys12-Tyr13-Leu14-Asp15-Ala16-Lys17-Arg18-Ala19-Gln20-Glu21-Phe22-Ile23-Glu24-Trp25-Leu26-Leu27-Gln28-Ser29-His30-Gln31-Gln32-His33-His34-Glu35-Ser36-Pro37-Pro38-Pro39-Lys42；Y2＝Z-Asn48-；Z＝i；R为C18直链亚烷基；实例号.604:His1-AIB2-His3-Gly4-Thr5-Phe6-Thr7-Ser8-Asp9-Tyr10-Ser11-Lys12-Tyr13-Leu14-Asp15-Ala16-Lys17-Arg18-Ala19-Gln20-Glu21-Phe22-Ile23-Glu24-Trp25-Leu26-Leu27-Gln28-Ser29-His30-His31-Gln32-His33-Glu34-Ser35-Pro36-Pro37-Pro38-Lys42；Y2＝Z-Asn48-；Z＝i；R为C18直链亚烷基；实例号.605:His1-AIB2-His3-Gly4-Thr5-Phe6-Thr7-Ser8-Asp9-Tyr10-Ser11-Lys12-Tyr13-Leu14-Asp15-Ala16-Lys17-Arg18-Ala19-His20-Glu21-Phe22-Ile23-Glu24-Trp25-Leu26-Leu27-Gln28-Ser29-His30-His31-Gln32-His33-His34-Glu35-Ser36-Pro37-Pro38-Pro39-Lys42；Y2＝Z-Asn48-；Z＝i；R为C18直链亚烷基；实例号.606:His1-AIB2-His3-Gly4-Thr5-Phe6-Thr7-Ser8-Asp9-Tyr10-Ser11-Lys12-Tyr13-Leu14-Asp15-Ala16-Lys17-Arg18-Ala19-His20-Glu21-Phe22-Ile23-Glu24-Trp25-Leu26-Leu27-Gln28-Ser29-His30-Gln31-His32-Glu33-Ser34-Pro35-Pro36-Pro37-Lys42；Y2＝Z-Asn48-；Z＝i；R为C18直链亚烷基；实例号.632:His1-AIB2-His3-Gly4-Thr5-Phe6-Thr7-Ser8-Asp9-Tyr10-Ser11-Lys12-Tyr13-Leu14-Asp15-Ala16-Lys17-Arg18-Ala19-Gln20-Glu21-Phe22-Ile23-Glu24-Trp25-Leu26-Leu27-Gln28-Ser29-His30-Gln31-His32-Gln33-His34-Pro35-Ser36-Pro37-Pro38-Pro39-Lys42；Y2＝Z-Asn48-；Z＝i；R为C18直链亚烷基；实例号.636:His1-AIB2-His3-Gly4-Thr5-Phe6-Thr7-Ser8-Asp9-Tyr10-Ser11-Lys12-Tyr13-Leu14-Asp15-Ala16-Lys17-Arg18-Ala19-Gln20-Glu21-Phe22-Ile23-Glu24-Trp25-Leu26-Leu27-Gln28-Ser29-His30-Gln31-His32-Gln33-His34-Pro35-Ser36-Pro37-Pro38-Pro39-Gly40-Lys42；Y2＝Z-；Z＝i；R为C18直链亚烷基；实例号.638:His1-AIB2-His3-Gly4-Thr5-Phe6-Thr7-Ser8-Asp9-Tyr10-Ser11-Lys12-Tyr13-Leu14-Asp15-Ala16-Lys17-Arg18-Ala19-Gln20-Glu21-Phe22-Ile23-Glu24-Trp25-Leu26-Leu27-Gln28-Ser29-His30-Gln31-His32-Gln33-His34-Glu35-Ser36-Pro37-Pro38-Pro39-Gly40-Lys42；Y2＝Z-；Z＝i；R为C18直链亚烷基；实例号.639:His1-AIB2-His3-Gly4-Thr5-Phe6-Thr7-Ser8-Asp9-Tyr10-Ser11-Lys12-Tyr13-Leu14-Asp15-Ala16-Lys17-Arg18-Ala19-Gln20-Glu21-Phe22-Ile23-Glu24-Trp25-Leu26-Leu27-Gln28-Ser29-His30-Gln31-His32-Gln33-His34-Glu35-Ser36-Pro37-Pro38-Pro39-Gly40-Lys42；Y2＝Z-Asn48-；Z＝i；R为C18直链亚烷基；实例号.642:His1-AIB2-His3-Gly4-Thr5-Phe6-Thr7-Ser8-Asp9-Tyr10-Ser11-Lys12-Tyr13-Leu14-Asp15-Ala16-Lys17-Arg18-Ala19-Gln20-Glu21-Phe22-Ile23-Glu24-Trp25-Leu26-Leu27-Gln28-Ser29-His30-Gln31-Gln32-His33-His34-Glu35-Ser36-Pro37-Pro38-Pro39-Gly40-Lys42；Y2＝Z-；Z＝i；R为C18直链亚烷基；实例号.643:His1-AIB2-His3-Gly4-Thr5-Phe6-Thr7-Ser8-Asp9-Tyr10-Ser11-Lys12-Tyr13-Leu14-Asp15-Ala16-Lys17-Arg18-Ala19-Gln20-Glu21-Phe22-Ile23-Glu24-Trp25-Leu26-Leu27-Gln28-Ser29-His30-Gln31-Gln32-His33-His34-Glu35-Ser36-Pro37-Pro38-Pro39-Gly40-Lys42；Y2＝Z-Asn48-；Z＝i；R为C18直链亚烷基；实例号.646:His1-AIB2-His3-Gly4-Thr5-Phe6-Thr7-Ser8-Asp9-Tyr10-Ser11-Lys12-Tyr13-Leu14-Asp15-Ala16-Lys17-Arg18-Ala19-Gln20-Glu21-Phe22-Ile23-Glu24-Trp25-Leu26-Leu27-Gln28-Ser29-His30-His31-Gln32-Gln33-His34-Glu35-Ser36-Pro37-Pro38-Pro39-Gly40-Lys42；Y2＝Z-；Z＝i；R为C18直链亚烷基；实例号.647:His1-AIB2-His3-Gly4-Thr5-Phe6-Thr7-Ser8-Asp9-Tyr10-Ser11-Lys12-Tyr13-Leu14-Asp15-Ala16-Lys17-Arg18-Ala19-Gln20-Glu21-Phe22-Ile23-Glu24-Trp25-Leu26-Leu27-Gln28-Ser29-His30-His31-Gln32-Gln33-His34-Glu35-Ser36-Pro37-Pro38-Pro39-Gly40-Lys42；Y2＝Z-Asn48-；Z＝i；R为C18直链亚烷基；实例号.652:His1-AIB2-His3-Gly4-Thr5-Phe6-Thr7-Ser8-Asp9-Tyr10-Ser11-Lys12-Tyr13-Leu14-Asp15-Ala16-Lys17-Arg18-Ala19-His20-Glu21-Phe22-Ile23-Glu24-Trp25-Leu26-Leu27-Gln28-Ser29-His30-Gln31-Gln32-His33-Glu34-Ser35-Pro36-Pro37-Pro38-Gly39-Lys42；Y2＝Z-Asn48-；Z＝i；R为C18直链亚烷基；实例号.653:His1-AIB2-His3-Gly4-Thr5-Phe6-Thr7-Ser8-Asp9-Tyr10-Ser11-Lys12-Tyr13-Leu14-Asp15-Ala16-Lys17-Arg18-Ala19-His20-Glu21-Phe22-Ile23-Glu24-Trp25-Leu26-Leu27-Gln28-Ser29-His30-Gln31-Gln32-His33-Glu34-Ser35-Pro36-Pro37-Pro38-Gly39-Lys42；Y2＝Z-；Z＝i；R为C18直链亚烷基；实例号.654:His1-AIB2-His3-Gly4-Thr5-Phe6-Thr7-Ser8-Asp9-Tyr10-Ser11-Lys12-Tyr13-Leu14-Asp15-Ala16-Lys17-Arg18-Ala19-Gln20-Glu21-Phe22-Ile23-Glu24-Trp25-Leu26-Leu27-Gln28-Ser29-His30-His31-Gln32-His33-His34-Glu35-Ser36-Pro37-Pro38-Pro39-Lys42；Y2＝Z-；Z＝i；R为C18直链亚烷基；实例号.655:His1-AIB2-His3-Gly4-Thr5-Phe6-Thr7-Ser8-Asp9-Tyr10-Ser11-Lys12-Tyr13-Leu14-Asp15-Ala16-Lys17-Arg18-Ala19-Gln20-Glu21-Phe22-Ile23-Glu24-Trp25-Leu26-Leu27-Gln28-Ser29-His30-Gln31-Gln32-His33-Ser34-Glu35-Ser36-Pro37-Pro38-Pro39-Lys42；Y2＝Z-；Z＝i；R为C18直链亚烷基；实例号.656:His1-AIB2-His3-Gly4-Thr5-Phe6-Thr7-Ser8-Asp9-Tyr10-Ser11-Lys12-Tyr13-Leu14-Asp15-Ala16-Lys17-Arg18-Ala19-Gln20-Glu21-Phe22-Ile23-Glu24-Trp25-Leu26-Leu27-Gln28-Ser29-His30-Gln31-Gln32-His33-His34-Glu35-Ser36-Pro37-Pro38-Pro39-Lys42；Y2＝Z-；Z＝i；R为C18直链亚烷基；实例号.657:His1-AIB2-His3-Gly4-Thr5-Phe6-Thr7-Ser8-Asp9-Tyr10-Ser11-Lys12-Tyr13-Leu14-Asp15-Ala16-Lys17-Arg18-Ala19-Gln20-Glu21-Phe22-Ile23-Glu24-Trp25-Leu26-Leu27-Gln28-Ser29-Gln30-His31-Gln32-His33-His34-Glu35-Ser36-Pro37-Pro38-Pro39-Lys42；Y2＝Z-；Z＝i；R为C18直链亚烷基；实例号.658:His1-AIB2-His3-Gly4-Thr5-Phe6-Thr7-Ser8-Asp9-Tyr10-Ser11-Lys12-Tyr13-Leu14-Asp15-Ala16-Lys17-Arg18-Ala19-Gln20-Glu21-Phe22-Ile23-Glu24-Trp25-Leu26-Leu27-Gln28-Ser29-Gln30-Gln31-His32-Glu33-Ser34-Glu35-Ser36-Pro37-Pro38-Pro39-Lys42；Y2＝Z-；Z＝i；R为C18直链亚烷基；实例号.660:His1-AIB2-His3-Gly4-Thr5-Phe6-Thr7-Ser8-Asp9-Tyr10-Ser11-Lys12-Tyr13-Leu14-Asp15-Ala16-Lys17-Arg18-Ala19-Gln20-Glu21-Phe22-Ile23-Glu24-Trp25-Leu26-Leu27-Gln28-Ser29-His30-His31-Gln32-Gln33-His34-Glu35-Ser36-Pro37-Pro38-Pro39-Lys42；Y2＝Z-；Z＝i；R为C18直链亚烷基；实例号.661:His1-AIB2-His3-Gly4-Thr5-Phe6-Thr7-Ser8-Asp9-Tyr10-Ser11-Lys12-Tyr13-Leu14-Asp15-Ala16-Lys17-Arg18-Ala19-Gln20-Glu21-Phe22-Ile23-Glu24-Trp25-Leu26-Leu27-Gln28-Ser29-His30-Gln31-Gln32-Gln33-His34-Glu35-Ser36-Pro37-Pro38-Pro39-Lys42；Y2＝Z-；Z＝i；R为C18直链亚烷基；实例号.663:His1-AIB2-His3-Gly4-Thr5-Phe6-Thr7-Ser8-Asp9-Tyr10-Ser11-Lys12-Tyr13-Leu14-Asp15-Ala16-Lys17-Arg18-Ala19-Gln20-Glu21-Phe22-Ile23-Glu24-Trp25-Leu26-Leu27-Gln28-Ser29-Gln30-Gln31-His32-Glu33-Ser34-Pro35-Pro36-Lys42；Y2＝Z-；Z＝i；R为C18直链亚烷基；实例号.671:His1-AIB2-His3-Gly4-Thr5-Phe6-Thr7-Ser8-Asp9-Tyr10-Ser11-Lys12-Tyr13-Leu14-Asp15-Ala16-Lys17-Arg18-Ala19-Gln20-Glu21-Phe22-Ile23-Glu24-Trp25-Leu26-Leu27-Gln28-Ser29-Gln30-Gln31-His32-Glu33-Ser34-Ser35-Gly36-Ala37-Lys42；Y2＝Z-；Z＝i；R为C18直链亚烷基；实例号.672:His1-AIB2-His3-Gly4-Thr5-Phe6-Thr7-Ser8-Asp9-Tyr10-Ser11-Lys12-Tyr13-Leu14-Asp15-Ala16-Lys17-Arg18-Ala19-Gln20-Glu21-Phe22-Ile23-Glu24-Trp25-Leu26-Leu27-Gln28-Ser29-His30-Gln31-His32-Glu33-Ser34-Ser35-Gly36-Ala37-Lys42；Y2＝Z-；Z＝i；R为C18直链亚烷基；实例号.673:His1-AIB2-His3-Gly4-Thr5-Phe6-Thr7-Ser8-Asp9-Tyr10-Ser11-Lys12-Tyr13-Leu14-Asp15-Ala16-Lys17-Arg18-Ala19-His20-Glu21-Phe22-Ile23-Glu24-Trp25-Leu26-Leu27-Gln28-Ser29-His30-Gln31-Gln32-His33-Glu34-Ser35-Ser36-Ala37-Ser38-Lys42；Y2＝Z-；Z＝i；R为C18直链亚烷基；实例号.678:His1-AIB2-His3-Gly4-Thr5-Phe6-Thr7-Ser8-Asp9-Tyr10-Ser11-Lys12-Tyr13-Leu14-Asp15-Ala16-Lys17-Arg18-Ala19-Gln20-Glu21-Phe22-Ile23-Glu24-Trp25-Leu26-Leu27-Gln28-Ser29-Gln30-Gln31-His32-Glu33-Ser34-Ser35-Gly36-Ala37-Lys42；Y2＝Z-Asn48-；Z＝i；R为C18直链亚烷基；实例号.682:His1-AIB2-His3-Gly4-Thr5-Phe6-Thr7-Ser8-Asp9-Tyr10-Ser11-Lys12-Tyr13-Leu14-Asp15-Ala16-Lys17-Arg18-Ala19-Gln20-Glu21-Phe22-Ile23-Glu24-Trp25-Leu26-Leu27-Gln28-Ser29-His30-His31-Gln32-Gln33-His34-Glu35-Gly36-Lys42；Y2＝Z-；Z＝i；R为C18直链亚烷基；实例号.691:His1-AIB2-His3-Gly4-Thr5-Phe6-Thr7-Ser8-Asp9-Tyr10-Ser11-Lys12-Tyr13-Leu14-Asp15-Ala16-Lys17-Arg18-Ala19-Gln20-Glu21-Phe22-Ile23-Glu24-Trp25-Leu26-Leu27-Gln28-Ser29-His30-His31-Gln32-Gln33-His34-Glu35-Ser36-Pro37-Pro38-Gly39-Lys42；Y2＝Z-；Z＝i；R为C18直链亚烷基；实例号.695:His1-AIB2-His3-Gly4-Thr5-Phe6-Thr7-Ser8-Asp9-Tyr10-Ser11-Lys12-Tyr13-Leu14-Asp15-Ala16-Lys17-Arg18-Ala19-Gln20-Glu21-Phe22-Ile23-Glu24-Trp25-Leu26-Leu27-Gln28-Ser29-His30-His31-Gln32-Gln33-His34-Glu35-Ser36-Ser37-Ser38-Gly39-Lys42；Y2＝Z-；Z＝i；R为C18直链亚烷基；实例号.700:His1-AIB2-His3-Gly4-Thr5-Phe6-Thr7-Ser8-Asp9-Tyr10-Ser11-Lys12-Tyr13-Leu14-Asp15-Ala16-Lys17-Arg18-Ala19-His20-Glu21-Phe22-Ile23-Glu24-Trp25-Leu26-Leu27-Gln28-Ser29-His30-Gln31-Gln32-His33-Glu34-Ser35-Pro36-Pro37-Pro38-Gly39-Lys42；Y2＝Z-Asn48-；Z＝i；R为C18直链亚烷基；实例号.701:His1-AIB2-His3-Gly4-Thr5-Phe6-Thr7-Ser8-Asp9-Tyr10-Ser11-Lys12-Tyr13-Leu14-Asp15-Ala16-Lys17-Arg18-Ala19-Gln20-Glu21-Phe22-Ile23-Glu24-Trp25-Leu26-Leu27-Gln28-Ser29-His30-His31-Gln32-Gln33-His34-Glu35-Ser36-Pro37-Pro38-Pro39-Gly40-Lys42；Y2＝Z-；Z＝i；R为C18直链亚烷基；实例号.704:His1-AIB2-His3-Gly4-Thr5-Phe6-Thr7-Ser8-Asp9-Tyr10-Ser11-Lys12-Tyr13-Leu14-Asp15-Ala16-Lys17-Arg18-Ala19-Arg20-Glu21-Phe22-Ile23-Glu24-Trp25-Leu26-Leu27-Gln28-Ser29-His30-Gln31-Gln32-His33-Glu34-Ser35-Pro36-Pro37-Pro38-Gly39-Lys42；Y2＝Z-Asn48-；Z＝i；R为C18直链亚烷基；实例号.705:His1-AIB2-His3-Gly4-Thr5-Phe6-Thr7-Ser8-Asp9-Tyr10-Ser11-Lys12-Tyr13-Leu14-Asp15-Ala16-Lys17-Arg18-Ala19-Arg20-Glu21-Phe22-Ile23-Glu24-Trp25-Leu26-Leu27-Gln28-Ser29-His30-Gln31-Gln32-His33-Pro34-Ser35-Pro36-Pro37-Pro38-Gly39-Lys42；Y2＝Z-Asn48-；Z＝i；R为C18直链亚烷基；实例号.706:His1-AIB2-His3-Gly4-Thr5-Phe6-Thr7-Ser8-Asp9-Tyr10-Ser11-Lys12-Tyr13-Leu14-Asp15-Ala16-Lys17-Arg18-Ala19-Gln20-Glu21-Phe22-Ile23-Glu24-Trp25-Leu26-Leu27-Gln28-Ser29-His30-Gln31-Gln32-His33-Pro34-Ser35-Pro36-Pro37-Pro38-Gly39-Lys42；Y2＝Z-Asn48-；Z＝i；R为C18直链亚烷基；实例号.707:His1-AIB2-His3-Gly4-Thr5-Phe6-Thr7-Ser8-Asp9-Tyr10-Ser11-Lys12-Tyr13-Leu14-Asp15-Ala16-Lys17-Arg18-Ala19-Gln20-Glu21-Phe22-Ile23-Glu24-Trp25-Leu26-Leu27-Gln28-Ser29-His30-Gln31-Gln32-His33-Pro34-Ser35-Ser36-Ser37-Ser38-Ala39-Lys42；Y2＝Z-Asn48-；Z＝i；R为C18直链亚烷基；实例号.708:His1-AIB2-His3-Gly4-Thr5-Phe6-Thr7-Ser8-Asp9-Tyr10-Ser11-Lys12-Tyr13-Leu14-Asp15-Ala16-Lys17-Arg18-Ala19-Gln20-Glu21-Phe22-Ile23-Glu24-Trp25-Leu26-Leu27-Gln28-Ser29-His30-Gln31-Gln32-His33-Pro34-Ser35-Ser36-Ser37-Ala38-Lys42；Y2＝Z-Asn48-；Z＝i；R为C18直链亚烷基；实例号.709:His1-AIB2-His3-Gly4-Thr5-Phe6-Thr7-Ser8-Asp9-Tyr10-Ser11-Lys12-Tyr13-Leu14-Asp15-Ala16-Lys17-Arg18-Ala19-His20-Glu21-Phe22-Ile23-Glu24-Trp25-Leu26-Leu27-Gln28-Ser29-His30-Gln31-Gln32-His33-Pro34-Ser35-Ser36-Ser37-Ala38-Lys42；Y2＝Z-Asn48-；Z＝i；R为C18直链亚烷基；实例号.711:His1-AIB2-His3-Gly4-Thr5-Phe6-Thr7-Ser8-Asp9-Tyr10-Ser11-Lys12-Tyr13-Leu14-Asp15-Ala16-Lys17-Arg18-Ala19-Gln20-Glu21-Phe22-Ile23-Glu24-Trp25-Leu26-Leu27-Gln28-Ser29-His30-Gln31-Gln32-His33-His34-Pro35-Ser36-Ser37-Ser38-Ala39-Lys42；Y2＝Z-；Z＝i；R为C18直链亚烷基；实例号.712:His1-AIB2-His3-Gly4-Thr5-Phe6-Thr7-Ser8-Asp9-Tyr10-Ser11-Lys12-Tyr13-Leu14-Asp15-Ala16-Lys17-Arg18-Ala19-Gln20-Glu21-Phe22-Ile23-Glu24-Trp25-Leu26-Leu27-Gln28-Ser29-His30-His31-Gln32-Gln33-His34-Pro35-Ser36-Pro37-Pro38-Pro39-Gly40-Lys42；Y2＝Z-；Z＝i；R为C18直链亚烷基；实例号.725:His1-AIB2-His3-Gly4-Thr5-Phe6-Thr7-Ser8-Asp9-Tyr10-Ser11-Lys12-Tyr13-Leu14-Asp15-Ala16-Lys17-Arg18-Ala19-Gln20-Glu21-Phe22-Ile23-Glu24-Trp25-Leu26-Leu27-Gln28-Ser29-His30-Gln31-Gln32-His33-Pro34-Ser35-Ser36-Ser37-Ala38-Lys42；Y2＝Z-Asn48-；Z＝i；R为C18直链亚烷基；并且实例号.726:His1-AIB2-His3-Gly4-Thr5-Phe6-Thr7-Ser8-Asp9-Tyr10-Ser11-Lys12-Tyr13-Leu14-Asp15-Ala16-Lys17-Arg18-Ala19-Arg20-Glu21-Phe22-Ile23-Glu24-Trp25-Leu26-Leu27-Gln28-Ser29-His30-Gln31-Gln32-His33-Pro34-Ser35-Ser36-Ser37-Ala38-Lys42；Y2＝Z-Asn48-；Z＝i；R为C18直链亚烷基。

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